Hello xy67,
I found that there were issues with this switch before: https://supportforums.cisco.com/discuss ... loss-speed, but, unfortunately, does not have any idea which setting could fix the issue.
As for LSFS question, with deduplication enabled, with 3 x 50 GB VMs, the 150 GB datastore will be full, but space, occupied by LSFS device, should be about 50-60 GB. At the same time, it could occupy more space because of data type and deduplication ratio.
The MPIO role should be installed in Windows in case if you are connecting the targets in Windows itself. For compute and storage separated scenario, there is no need to enable MPIO.
Usually, StarWind devices show in ESXi as Non-SSD. You can check it from GUI or alternatively you can run "esxcli storage core device list" command to list all disk devices and their properties. There should be the line "Is SSD:" which reports about disk type.
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